Endocrine Abstracts

Aim: We investigated the influence of mitochondrial dysfunction associated with aging on physical performance in mice, and the effect of hormone replacement on physical performance.Method: Using 8, 20, 50 and 100 week-old C57bl6 mice, we evaluated skeletal muscle mass, mitochondrial activity, glucose tolerance and physical performance (muscle power and exercise endurance). In addition, we treated 50-week-old mice with ghrelin or insulin like growth facto...

Background: Chronic kidney disease (CKD) in human has been believed to decrease muscle weight and physical performance. High protein diet would increase muscle mass and strength especially in athletes, but is not recommended for CKD patients because of the risk for exacerbation of uremia. Therefore, we investigated the muscle character especially focused on the mitochondrial activity and physical performance in 5/6 nephrectomy CKD model mice, which fed on different protein con...